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Because we considered a disruption of a thickened epidermis an extreme state of eczema and the repair of these areas an essential process in healing, we initially quantitated the effects of 1 M solutions of the peptides when included in the topical application with LPS or administered by subcutaneous injection of 1 nmol/g

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Gabapentinoids, including gabapentin and pregabalin, bind to the 2 subunit of presynaptic voltage-gated calcium channels, reducing calcium influx and subsequent release of excitatory neurotransmitters, such as glutamate, noradrenaline, and substance P [67,68,69,70]

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