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In some embodiments, the formulations or compositions described herein have a pH and osmolarity as described herein, and have a concentration of active pharmaceutical ingredient between about 1 M and about 10 M, between about 1 mM and about 100 mM, between about 0.1 mM and about 100 mM, between about 0.1 mM and about 100 nM

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has traditionally been used as an eyewash to address and prevent a range of eye conditions, including conjunctivitis, blepharitis, eye fatigue, purulent ocular inflammation, and styes [170]