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Studies in perinatology have used doses ranging from 300 mg/kg 13 to 1 g/kg 14

Arsenite led to the downregulation of OsLsi1 and OsLsi2 , influenced thiol metabolism, enhanced PCs level, and reduced GSH content and GSH/GSSG ratio which was reversed by NO supplementation

They found that high-dose IGF-1 was beneficial to cartilage formation, while low-dose IGF-1 was more conducive to subchondral bone reconstruction [35]

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J Pharm Biomed Anal 143:130140 Cantaert T, Brouard S, Thurlings RM, Pallier A, Salinas GF, Braud C, Klarenbeek PL, de Vries N, Zhang Y, Soulillou JP (2009) Alterations of the synovial T cell repertoire in anti-citrullinated protein antibody-positive rheumatoid arthritis