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The exact reasons for this have not been fully established but been suggested to be the effect of Arg-112 making ApoE4 in a tighter locked conformation than ApoE3 or ApoE2, thus hindering the lipid insertion site (Chen et al., 2021

and various cardiovascular diseases, including heart failure, myocardial infarction, and arteriosclerosis [11,12,13,14,15]

Antioxidants vitamin C, selenium, and coenzyme Q10

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These medications target specific immune pathways to reduce inflammation