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Il demeure au repos pendant 1 h dans une enceinte thermostate qui maintient la temprature rectale de l'animal 38 o C, tout au long de la manipulation.The animal is placed on a cork board, the left hind leg fixed at the level of the tibia using a trigger guard stabilizing the preparation

13 Additionally, lactylation of TFEB at lysine 91 in tissues of PDA patients prevents its interaction with the E3 ubiquitin ligase WWP2, reducing TFEB ubiquitination and degradation, and thereby increasing its activity and autophagy flux, contributing to pancreatic cancer

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Cancer Discov 2013

For instance, the mitochondrial shuttle-system allows the transport of fatty acids, as acylcarnitines, from the cytosol into the mitochondrial matrix where these nutrients are oxidized for ATP production

Sptere Metaanalysen berichten ebenfalls von geringen, aber signifikanten Reduktionen des Krpergewichts, des BMI oder der Fettmasse, wobei die Effekte bei bergewichtigen oder adipsen Personengruppen strker ausgeprgt waren