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Extracellular matrices and cancer-associated fibroblasts: Targets for cancer diagnosis and therapy

Craft S, Asthana S, Cook DG, Baker LD, Cherrier M, Purganan K, et al

The role of -smooth muscle actin in fibroblast-mediated matrix contraction and remodeling

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10.3389/fimmu.2022.837669 [DOI] [PMC free article] [PubMed] [Google Scholar] Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, et al

This immune surveillance reduces antigen presentation by the MHC-I complex, associated with downregulation of activating ligands for NK cells or reduces the antitumor activity of cytotoxic T cells.58 Taken together, all of these studies suggest that NRF2 contributes to immunosuppression in cancer through multiple mechanisms