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doi:10.1177/15648265080292S107
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Contrarily, a study with 8 GH-deficient subjects found that IGF-1 administration increased lipid oxidation (being this effect more potent when co-administered with GH), energy expenditure, and insulin resistance [108, 183]
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Recent efforts have focused on the use of drugs already approved by the Food and Drug Administration (FDA) for other diseases that have also shown efficacy in delaying cystogenesis, including pioglitazone, sirolimus, and metformin (Table 1) [912]
The results were unambiguous
