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Another drug repurposed is metformin (clinically used as an anti-diabetic) which is being used as an AMPK activator, currently in phase II clinical trials for CLL (ClinicalTrials.gov: NCT01750567) (105, 106)

There is controversy surrounding the bodys ability to absorb glutathione in the intestinal tract

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DA-P-SS-T/PTX nano-micelles rapidly release drugs at high GSH levels, leading to apoptosis in drug-resistant lung cancer cells [100]

doi: 10.1016/j.rbmo.2022.05.010 129 WangLTangJWangLTanFSongHZhouJet al

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