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Dihexa: A Cautionary Tale Dihexa exemplifies the gap between preclinical hype and clinical reality

Key Highlights AOD9604 activates lipolytic pathways through beta-3 adrenergic receptor upregulation and cAMP-PKA-HSL cascade activation in adipocytes The peptide inhibits acetyl-CoA carboxylase to suppress lipogenesis while promoting fatty acid oxidation in laboratory models Research confirms no IGF-1 stimulation or glucose metabolism disruption, distinguishing it from full-length growth hormone Cartilage studies show proteoglycan synthesis enhancement and improved tissue structure in osteoarthritis animal models What is AOD9604

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doi: 10.7326/M15-0114 530 Castro-MarreroJSez-FrancsNSantilloDAlegreJ