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In particular, there is some evidence that eryptotic cells might undergo swelling, which is much less common [89]

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Notably, the mortality rate of endometrial cancer has steadily increased annually by approximately 1% (Siegel et al., 2023) Despite the twofold increase in the incidence of ovarian cancer in developed nations, the cumulative mortality risk remains similar between developed and developing regions (Zhang et al., 2019)

doi: 10.1002/cncr.v126.14 192 CronkRJZurkoJShahNN

Figure 9 Statements Author contributions MN: Writing original draft

Additionally, loss of phosphate groups from multiply phosphorylated metabolites (e.g., ATP, GTP) upon electrospray ionization can skew the metabolite distribution of the sample toward lower phosphorylation states