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3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for softtissue homeostasis, are compromised by ferroptosis through a twofold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosisassociated ROS and proinflammatory mediators ( in vitro primary cell models, indicate that ferroptosis in periodontal ligament fibroblasts serves as an active driver of soft tissue destruction

Chen R, McVey DG, Shen D, Huang X, Ye S

BealMF.Mitochondria, free radicals, and neurodegeneration

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MuRF1, muscle-specific RING finger protein 1

The inhibition of CB2 receptors resulted in the suppression of basal lipid production, suggesting that CB2 antagonists may be helpful in the treatment of skin conditions characterized by the dysfunction of the sebaceous gland [100]
