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As an exposure-based control, cells passaged for five days but not previously exposed to Zn were also tested

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While rodent modelsparticularly those avoiding confounding physiological effects of high systemic chemotherapy doseshave provided valuable insight, validation of the mechanisms of CIPN in patients has been difficult not least because of the extensive co-morbidities usually present in this patient group

The infectious dose is unknown but is believed to be only a few virions

Short-term antioxidant effects 2

Both may support the liver's stores of glutathione