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Waheed SM, Ghosh A, Chakravarti R, Biswas A, Haque MM, Panda K, et al
In the heart, the metabolome is characterized by amino acid depletion, evidence of altered redox balance including glutathione depletion, and a shift from oxidative phosphorylation to alternative energy production pathways
The subsequent oxidative damage includes mitochondrial DNA (mtDNA) injury, opening of the permeability transition pore (mPTP), and initiation of apoptotic pathways [100]
Battelino T, Bergenstal RM, Rodrguez A, Fernndez Land L, Bray R, Tong Z, et al
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