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Watanabe F, et al

ROS is a known inducer of cell proliferation (73)

MDSUPDRS motor scores and data on dopaminergic treatment were not available for the subjects covered for the transcriptomics profiling, and therefore the comparison of metabolomics and transcriptomics data focused on the case-control analyses and shared network alterations, confirming the treatment-independence using the metabolomics data (see section on Pathway and network analyses below)

Similarly, growth hormone (GH) may be related to ALS as one trial found that ALS patients had impaired GH secretion compared to healthy controls (Morselli 2006)