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It is worth noting that neutralizing antibodies frequency is lower for intramuscular interferon beta 1a (which has been associated with the lowest frequency of NAbs, 2% to 6%) (50

doi: Peer reviewed and published scientific report

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

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This modification increases molecular size, reduces renal clearance, and shields the peptide from enzymatic degradation [264]
