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Elsevier, Amsterdam

Eye involvement requires prompt medical evaluation because shingles in the ophthalmic branch can threaten vision
The immune system has different branches, primarily Th1 and Th2

However, receptor desensitization can occur with prolonged use, reducing effectiveness

The combination of GLP-1 and GIP activation is what separates tirzepatide from pure GLP-1 agonists like semaglutide, and clinical data suggests the dual mechanism produces superior weight loss outcomes
Retatrutide remains investigational as of May 2026