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The efficacy of TMZ is intricately linked to the proper functioning of the MMR system, which explains why the downregulation of MLH1 can result in resistance to TMZ [161]

Funding This study was funded by a Special Coordination Fund for Promoting Science and Technology, Creation of Innovative Centers for Advanced Interdisciplinary Research Areas (Innovative Bioproduction, Kobe) from the Ministry of Education, Culture, Sports, and Science and Technology (MEXT), Japan
Ozone, a highly oxidative gas harmful upon direct contact with the human body (26), has been Ozone has a historical application in surgery for sterilization and disinfection (2729)

in 1976 [3]
Heidari R, Ghanbarinejad V, Ommati MM, Jamshidzadeh A, Niknahad H, Mohammadi H, Sayad A, Mohammadi M, Niknahad H, Heidari R (2020) N-acetyl cysteine treatment preserves mitochondrial indices of functionality in the brain of hyperammonemic mice
