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Initially, injections are given daily or every other day for a week, then weekly for 12 months, followed by monthly maintenance

Acknowledgements This work was supported by the National Natural Science Foundation of China (81170409, 81101720), the National S&T Major Special Project on Major New Drug Innovation (2012ZX09301002-001), the Wang Bao En Liver Fibrosis Foundation (20110026), and the Sichuan Provincial People's Hospital Doctor's Foundation (30305030828)