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Challenges traditional dogma that hypertrophic chondrocytes die by apoptosis and demonstrates that chondrocytes can directly transform into bone during fracture repair

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Pentose phosphate pathway (PPP) is a cytoplasmic side-road that splits from glycolysis at glucose-6-phosphate (G6P)

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For example, in vivo studies have shown significantly reduced proliferation rates in PC3 prostate cancer cell lines in IGF1deficient hosts, compared to control hosts 66