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[DOI] [PubMed] [Google Scholar] 34.Bartl M, Xylaki M, Bahr M, Weber S, Trenkwalder C, Mollenhauer B

Its extremely long biological half-life (about 2030 years) and low rate of excretion from the body lead to Cd continuous bioaccumulation in soft tissues (Rikans and Yamano, 2000) and kidney (Satarug, 2018), even our heart (Peters et al., 2010), including cardiac death and myocardial infarction ( It is universally acknowledged that oxidative stress is the major event induced by Cd poisoning (Liu et al., 2009)

Acting as immunostimulants, prebiotics directly impact the fishs innate immune system

doi: 10.1183/13993003.01124-2017 141

PLoS ONE 9(2):e87885 Van de Wouw M, Schellekens H, Dinan TG, Cryan JF (2017) Microbiota-gut-brain axis: modulator of host metabolism and appetite

On one hand, copper acts as a co-factor for numerous enzymes by facilitating electron transfer