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A well-powered, blinded topical trial 200+ participants, independent sponsorship, standardized outcome measures would settle the skin aging and wound healing signal sizes for good

The Compounding Effect Benefits at this stage reflect accumulated improvements rather than sudden changes

Transl Sci

doi: 10.1007/s11060-022-03964-2 [DOI] [PubMed] [Google Scholar] 68

Additionally, while targeting TGF- and its downstream effectors presents a promising therapeutic strategy for fibrosis, the challenge lies in achieving specificity and minimizing impacts on normal cellular functions

According to Smith and Refsum (2021), homocysteine values of 10mol/L are probably safe in adults but for levels 11mol/L or above there may be a risk for adverse effects, justifying intervention