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Mitochondria are the main producer of reactive oxygen species (ROS) and free oxygen radicals, which include ozone (O 3 ), singlet oxygen ( 1 O 2 ), superoxide radical anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (HO ), which are extremely chemically reactive and can react with virtually all substances in the cell [20]

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Genoveva Bern, [email protected] These authors have contributed equally to this work These authors have contributed equally to this work and share senior authorship This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This is why its often preferred by people aiming for fat loss without side effects, especially those who want a more sustainable and balanced approach

The study group comprised 80 healthy subjects aged 2165 years

Nuclear mechanisms of insulin resistance