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37,38 An initial concentration below the nomogram line may rarely cross the line in patients who ingest acetaminophen preparations known to have prolonged absorption kinetics

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Topical corticosteroids in melasma therapy have a dual purpose: (1) they may directly lighten hyperpigmented lesions by reducing melanin-stimulating inflammation, and (2) they temper the skins inflammatory response to irritants like tretinoin and hydroquinone, thereby improving patient tolerance

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