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Highlights of prescribing information: Zytiga [online], (2013)

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When delivered intranasally, its absorbed through the nasal mucosa into the bloodstream, allowing for quicker access to the brain and the central nervous system

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[DOI] [PubMed] [Google Scholar] Sithigorngul P, Burton P, Nishihata T, Caldwell L

(We provide a range because the final negotiated amount is not made public.) After the first failed inspection, FDA issues a Warning Letter and begins to issue fines for any subsequent compliance check failures