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Increment in collagen content could also be clearly observed

Norheim, K

2a & Supplementary Fig
doi: 10.1126/science.1069492

Ijms 20, 3711
A critical maladaptation is the dysregulation of ion channels, specifically the pathological upregulation and altered trafficking of voltagegated sodium channels (e.g., Nav1.3, Nav1.7, Nav1.8) and Ntype calcium channels [54, 57, 58, 71]