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Methionine synthases catalyze the final reaction in the methionine biosynthesis pathway, i.e., the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, thus generating tetrahydrofolate and methionine

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This level of metabolic resolution demonstrates the methods potential to uncover novel biological insights into toxicological mechanisms

Furthermore, this integrative approach enhanced the overall efficacy of Western medical treatment

Glycogen is an evolutionary conserved antioxidant Because the de novo synthesis of cytoprotective enzymes is not necessary for glucose-mediated resistance to oxidants (Supplementary Table 1), we expected that the addition of glucose while challenging animals with an oxidant should be sufficient to protect them