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Cell Chem Biol 27:365375 Costa I, Barbosa DJ, Benfeito S, Silva V, Chavarria D, Borges F et al (2023) Molecular mechanisms of ferroptosis and their involvement in brain diseases

Persistent activation of mtCB1R in astrocytes reduces mitochondrial complex I stability and ROS production

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The above studies demonstrate that YAP is crucial in regulating both the initiation and development of ferroptosis, and Yap can be a good candidate target for lung cancer therapy

Accordingly, in ADH5 cells, FA was also able to induce the oxidation of the dye dihydroethidium (DHE), which reports the presence of superoxide and non-specific oxidant species (Fig