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Osteogenic growth peptide (OGP) OGP is a naturally occurring, highly conserved, 14-amino acid, H4 histone-related peptide [81], abundant in human and mammalian blood as well as in culture media of osteoblasts and fibroblasts [81, 82]

It was first isolated in 1974 from the cerebral venous blood of rabbits in a sleep state by Monnier and colleagues, making it one of the earlier identified endogenous neuropeptides associated with sleep-wake cycle regulation research

Interestingly, keratin fibers from the dressing were incorporated in the regenerating tissue during the healing process

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