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Authors' contributions AG performed the investigations described in this study
In brief, when TrkB and p75 NTR co-express in the same cells, p75 NTR enhances neurotrophin binding to TrkB, augmenting both ligand affinity and selectivity, hence, reinforcing the TrkB-mediated trophic response via up-regulation of PI3K/Akt and/or IRAK/NF-B signaling 3
Grecksch G, Bartzsch K, Widera A, Becker A, Hollt V, Koch T: Development of tolerance and sensitization to different opioid agonists in rats

Hydroxocobalamin is considered safe for use during pregnancy and breastfeeding when clinically indicated
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2022, doi: 10.1212/WNL.0000000000200713.
