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[1] The shuttle is regulated at the CPT-I level, being inhibited by malonyl-CoA from beta oxidation, preventing a futile cycle

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Interestingly, 67% of this subset of children with ASD demonstrated neurodevelopmental regression, which is a particularly high rate compared to the general ASD population [about 25% (8)]

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Iwanaga, J, Tabira, Y, Fisahn, C, Alonso, F, Watanabe, K, Kusukawa, J, Oskouian, RJ, Tubbs, RS, and Yamaki, KI (2017)