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In the early stage of alveolar injury, neutrophils are recruited into the injured sites, triggering an immune response by releasing pro-inflammatory cytokines and producing neutrophil elastase (NE) to exacerbate fibrosis (Le Saux and Chapman, 2018)

This can be important given GABAARs, as members of the Cys-loop family of pentameric transmembrane ligand-gated ion channels, expressed in parts of the nervous system that process higher-order brain functions and have influences on regulating synaptic transmission and integration of synaptic signals central to memory, awareness, and consciousness [226]

Polycythemia vera is another cause
Role of nutritional supplementation in reducing the levels of homocysteine

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