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However, despite its important applications, only one TDC structure from Methanococcus jannaschii (PDB code: 3F9T, Mj TDC) has been resolved and deposited in the PDB database, and the key residues responsible for substrate binding and the catalytic mechanism remain unclear

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doi: 10.3390/ijms20205232

Neither of the drugs resulted in a permanent regression of the tumor

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