slc25a39 is necessary for mitochondrial glutathione import in mammalian cells Combinatorial GxGxE CRISPR screen identifies transport linking iron homeostasis to OXPHOS SLC25A39 is necessary for mitochondrial
Description
Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: Tissue-specific variations and roles in oxidative stress
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Fact: Standard oral glutathione has very low bioavailability
This significantly enhanced the accumulation of cisplatin in tumor cells, increasing efficacy in cisplatin resistant cells and decreased tossicity 95
GSH neutralizes reactive oxygen and nitrogen species, supports the activity of antioxidant enzymes like glutathione peroxidases (GPx) and glutathione S-transferases (GST), prevents irreversible protein oxidation through glutathionylation, and participates in detoxification through conjugation [47]
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