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On endoscopic examination, mild ischemia is characterized by granular mucosa with decreased vascularity, whereas friable, edematous, ulcerated, and at times necrotic mucosa is evident in severe cases

However, we used different analytic methods robust to pleiotropy, which gave a similar interpretation

Int J Mol Sci (2020) 21:3425

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It could place them in Category 1, allowing them to be used in compounding