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The gut may have problems with absorbing certain vitamins and minerals, perhaps due to a condition or illness such as Pernicious Anaemia, Crohns and Coeliac disease

J Neurochem 97(6):16761689 Goureau O, Regnier-Ricard F, Courtois Y (1999) Requirement for nitric oxide in retinal neuronal cell death induced by activated Muller glial cells

132,133,134 BER dysfunction leads to error propagation, DNA breaks, and genomic instability, 135,136 leading to the progression of several diseases, including cancer, immune deficiency, and neurodegenerative diseases

10.15252/embj.2019103256 EMBO J

First, dose-limiting toxicities arise because glycolysis is essential for normal tissues including brain, red blood cells, and immune cells

2018, doi:10.1155/2018/4836736 Choi, Sohyeon et al