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Even though some enzymes have been identified as possible therapeutic targets, the intricate interactions between various pathways necessitate a more organized, multitarget, process-directed therapeutic approach that seeks to concurrently interfere with several oncogenic processes in order to reduce the number of potential escape mechanisms that tumors may use (120)
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The results showed that the depletion of Pink1 considerably reduced CCCP-induced mitophagy in HeLa229/g-CTL cells (Figs
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