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Spearman correlation between the protein abundance of 11 genes including MTA1 (red) within C38 and mono-like score in this cohort

1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])

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Plasma amino acid analysis revealed a decrease in the methionine level and a marked elevation in the plasma homocysteine level, whereas other essential amino acids were within normal ranges (methionine, 15.2 mol/L [18.940.5 mol/L]

doi: 10.1007/s00441-004-0938-y 121 ShahmoradianS

To view a copy of this licence, visit About this article Cite this article Bramble, M.S., Fourcassi, V., Vashist, N