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Overall, ALA emerges as a promising alternative for alleviating metal toxicity by enhancing antioxidant defenses, chelating toxic metals, and reversing their harmful effects

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or CJC-1295 (DAC) : single weekly dose (microgram-per-kg style dosing in clinical formulations)

NAC was obtained from the Jefferson Pharmacy as Acetadote (Cumberland Pharmaceuticals)

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Interestingly, in Arabidopsis suspension cells transcriptional up-regulation of GCL in response to various oxidative stresses was not observed, even though both GCL activity and cellular glutathione levels increased (May et al., Localization of Glutathione Synthesis in Plants The localization of GCL and GS plays a major role in the biosynthesis of glutathione