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Total DNA was extracted using the extraction reagent (DNA zol BD Reagent, Invitrogen) following homogenization

P1167 Dhifallah M

Jiang, Y., Oliver, P., Davies, K

10.1016/j.bbi.2012.12.011 Brain Behav

Javier Echeverra, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]