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The first vaccine, developed by Sanofi Pasteur, used formalin-inactivated full-length toxins TcdA and TcdB, but the vaccines development was halted after phase III clinical trials

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Int J Fertil 1977;22:85-91

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And for many users, the fatigue is significant enough to affect daily functioning, work performance, and exercise capacity

Furthermore, genetic variants of organic cation transporter 2 reduce cardiac uptake of carnitine, leading to heart failure [32]