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81 Daratumumab was originally selected from a panel of 42 CD38specific mAbs based on potent CDC activity 87 and its efficacy has been shown to be negatively impacted by higher expression of complement inhibitory proteins CD55 and CD59, of which the former is found on chromosome 1q

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References Yang, B., Good, D., Mosaiab, T., Liu, W., Ni, G., Kaur, J., Liu, X., Jessop, C., Yang, L., Fadhil, R., Yi, Z., & Wei, M