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Sampled heteroplasmy was then plotted against the simulated true heteroplasmy, with cells sampled at depth 0.25, p.adj 0.25, p.adj T mouse and MEFs
These include high molecular weight, limited cellular uptake, and susceptibility to enzymatic degradation by nucleases in vivo
Roomi MW, House D, Tsao CS: Cytotoxic effect of substitution at 2-, 6-, and 2,6-positions in ascorbic acid on malignant cell line
Disease is often asymptomatic or mild, but may cause generalized illness like influenza, meningitis, or encephalitis
Vhora et al
