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Sirpiglenastat (Drp-104) induces antitumor efficacy through direct, broad antagonism of glutamine metabolism and stimulation of the innate and adaptive immune systems

Nevertheless, the results show that the redox environment in the ER is more oxidizing than the cytosol and that GSSG must be generated through an oxidative pathway

Q: How is this different from taking glutathione and collagen separately

Bernasocchi, T

Curr Med Chem (2017) 24(14):14691485

Although several steps in this proposed general mechanism still need detailed confirmation in ex vivo in vitro and in in vivo models through combined metallomic-metabolomic approaches [211,212] and through a systematic physico-chemical study of the involved molecular systems, the collected information allows us to design experimental approaches aimed at verifying the missing steps of the comprehensive model