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10.1111/j.1474-9726.2005.00160.x Aging Cell 61 Valdovinos-FloresC.GonsebattM

Acknowledgements This work was supported in part by the Rehabilitation Research & Development Service of the US Department of Veterans Affairs Office of Research and Development and The Cleveland Clinic

Loss of 'tone' of the bowel muscles in older people Pregnancy Medicines such as morphine or codeine Having to stay in bed for a long time Lack of exercise Whatever the cause, constipation can be uncomfortable

In fact, over 95 per cent of drugs do not show useful activity in the brain and many show poor penetration of the BBB

For information about risks and side effects, read the package leaflet and ask your doctor or pharmacy