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Moreover, a cornucopia of experimental models has illustrated the protective effect of NLRP3 gene deletion in different types of renal disease, such as necrotic cell induced sterile inflammation, diabetic nephropathy, renal ischemia-reperfusion-injury (IRI), unilateral ureteral obstruction and glomerular disease [76, 77, 78, 84, 85]

Lead (Pb) binds to sulfhydryl and amide group components of enzymes, altering their configuration and diminishing their activities

CT-1 and CT-3 promoted melanin synthesis in mouse B16 melanoma cells, but CT-2 inhibited melanin synthesis without cytotoxicity (Ochiai et al., 2016)

As a CPP, FOXO4-DRI differs from these by being designed around a specific amino acid sequence in a molecular target only mildly expressed in most normal tissues (see e.g

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Artemisinin derivatives stimulate DR5-specific TRAIL-induced apoptosis by regulating wildtype P53