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It helps activate and regulate various immune cells, including T-lymphocytes and natural killer cells

The lipophilic unconjugated bilirubin is transported within the circulation bound to albumin [149]

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The relatively slow pace for developing efficient vaccines is due, at least in part, to the typical complex life cycles of the responsible agents, our limited knowledge of protective immune mechanisms, and the fact that parasites are well adapted to their hosts and evolved complex and efficient mechanisms of immune evasion, including antigenic variation