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Glutathione conjugates experience removal of the -glutamyl moiety via either GGT on the renal brush-border membrane or through other GGT-expressing cells such as the vasculature, which is followed by the removal of Gly units via extracellular dipeptidases (Figure 2)

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Under low cholesterol conditions, Insig- 1 is degraded, allowing the SCAP-SREBP- 2 complex to enter COPII vesicles for transport to the Golgi apparatus

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