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Moreover, the communication between MAMs and the coordination of Ca 2+ flux from the ER to mitochondria are pivotal for triggering oxidative metabolic stress, a ROS surge, and an ensuing pro-paraptotic Ca 2+ overload in breast cancer cells [153]

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Research indicates that the DHODH pathway can protect cells from oxidative stress and mitochondrial damage through various mechanisms, including downregulating ROS levels, maintaining mitochondrial membrane potential, and inhibiting cell apoptosis (77, 78)

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Vitamin B12, also known as cobalamin, and folate, also known as vitamin B9, are two essential members of the B-complex vitamin family