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An evaluation of the issues associated with the use of metformin and vitamin B 12 status that are clinically relevant and significant to most healthcare practitioners appeared in an editorial in The New Zealand Medical Journal entitled A safe and effective drug?

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Thus, serum vitamin B12 levels can be falsely normal in cases of liver damage, alcoholism, or myeloproliferative syndrome and falsely decreased in other situations, such as pregnancy

intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency"

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