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In this regard, in humans, it has been suggested that an increase in the frequencies of protective variants in detoxification genes might be due to a mechanism of adaptation to toxic environmental metal tolerance 21

10.1016/j.freeradbiomed.2009.11.018 [DOI] [PubMed] [Google Scholar] Bumer D., Talbot K., Turner M

Adding astaxanthin to this mix adds a layer of protection that glutathione cannot provide on its own, particularly regarding the structural integrity of cell membranes

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& Gershenzon, J

Indeed, the permeability of the intestinal mucosa is considered a crucial factor in innate defense, and disruption of barrier function can lead to excessive activation of immune cells (127)